Duragesic® Skin Patch



What is Duragesic® Skin Patch?

Duragesic® is a skin patch containing fentanyl, an opioid pain medication.

Duragesic patches are a powerful prescription pain medicine. The patches are designed to treat moderate to severe chronic pain in opioid-tolerant patients that is severe enough to require daily, around-the-clock opioid treatment for a long period of time.

Duragesic patches are used when other pain medications, such as non-opioid pain medications or immediate-release opioid pain medications, are ineffective or are not tolerated.

Duragesic patches should not be used to treat minor or irregular pain or pain caused by surgery. The patches should not be used to treat pain that isn’t persistent.

How to use Duragesic® Skin Patch

  • Follow your doctor’s instructions for using Duragesic patches. Read all drug guidelines and follow the directions on your prescription label.
  • Duragesic patches should never be used in bigger amounts or for longer than prescribed. If you have an increased urge to take more fentanyl, tell your doctor. If a skin patch has been sliced or damaged, do not use it.
  • Stop taking any additional opioid medications (around-the-clock opioid medications) such as Oxycontin®, Roxicodone®, Xtampza®, Belbuca®, Suboxone®, etc., while using Duragesic® skin patches.
  • Do not allow the Duragesic skin patch to come into contact with your mouth, eyes, nose, or lips, or another person’s skin
  • Wear the Duragesic skin patch around the clock, removing and replacing the patch every 72 hours (3 days). Do not wear more than 1 patch at a time unless your doctor has told you to.
  • When placing a skin patch on a young child, choose a wearing area where the child cannot easily remove the patch unsupervised.
  • Do not stop using Duragesic suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using Duragesic.
  • Store each patch in its foil pouch at room temperature.
  • Keep both used and unused patches out of the reach of children or pets. The amount of fentanyl in a used skin patch can be fatal to a child or pet who accidentally sucks or chews on the patch. Seek emergency medical attention if this happens.
  • After removing a Duragesic patch: fold it in half with the sticky side in, and flush the patch down the toilet right away. Do not place a used skin patch into a trash can.

Side Effects of Duragesic® Patch

Common side effects of Duragesic® Patch may include:

  • headache, dizziness, drowsiness, tiredness;
  • nausea, vomiting, stomach pain, diarrhea, constipation;
  • itching, redness, or rash where a patch was worn;
  • sleep problems (insomnia); or
  • increased sweating, or cold feeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

Get emergency medical help if you have signs of an allergic reaction to Duragesic: hives; chest pain, difficult breathing; swelling of your face, lips, tongue, or throat.


50 mcg/hr, 75 mcg/hr, 100 mcg/hr


5 Patches, 10 Patches, 20 Patches




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